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Details Coversyl Generic Name: Perindopril Packets of 30 x 4 mg Tablets Manufactured by Douglas Pharmaceuticals Use Coversyl (perindopril) is a long-acting ACE inhibitor with a high affinity for tissue ACE. Due to its unique mechanism of action, proven efficacy, hemodynamic tolerance and cardiovascular properties, Coversyl is an ideal first-line choice agent in the treatment of hypertension at the dosage of 4 mg to 8 mg if greater BP decrease is needed, or if patients is already at higher risk. Coversyl is also indicated in heart failure at the initial dosage of 2 mg and 4 mg maintenance dosage. Dosage Coversyl is an ideal first-line choice agent in the treatment of hypertension at the dosage of 4 mg to 8 mg if greater BP decrease is needed, or if patients is already at higher risk. Coversyl is also indicated in heart failure at the initial dosage of 2 mg and 4 mg maintenance dosage. How Coversyl works Coversyl (Perindopril) belongs to a group of medicines called ACE inhibitors which block the action of a chemical in the body called angiotensin converting enzyme (ACE). Normally ACE produces another chemical, angiotensin. Thus perindopril reduces the amount of angiotensin in the blood. Angiotensin has two actions. Firstly it acts on blood vessels to make them narrow and secondly it acts on the kidney to produce less urine. As perindopril stops the production of angiotensin, these actions are reversed. Therefore more urine is produced by the kidneys, which results in less fluid in the blood vessels. The blood vessels also widen. The overall effect of this is a drop in blood pressure and a decrease in the workload of the heart. Side effects More common side effects of Coversyl may include Rash; Disturbed sleep; Changes in mood; Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain; Dry cough; Severe swelling of lips, face or tongue (angioedema); Dizziness; Alteration in taste; Profound drop in blood pressure (hypotension); Disorders of the blood, kidney or liver; Decreased kidney function. Precautions Coversyl should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor. Coversyl passes into breast milk. Seek medical advice from your doctor before using this medicine during breastfeeding. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. The blood pressure lowering effect of perindopril is increased by:- - Other blood pressure reducing agents - Anaesthetics Non-Steroidal Anti-Inflammatory Drugs (eg ibuprofen) reduce the effect of perindopril on lowering blood pressure and may increase the risk of kidney damage. When given with lithium, the levels of lithium in the blood may be increased. If given with the immunosuppressant, e.g. cyclosporin, non-steroidal anti-inflammatory drugs (NSAIDS), potassium retaining water tablet (diuretics) or potassium salts there is an increased risk of raised level of blood potassium (hyperkalaemia).