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Details EFFEXOR XR – (Venlafaxine HCI) Packets of 28 x 150 mg Capsules. Manufactured by Wyeth-Ayerst Laboratories What is it? Effexor XR is an extended release serotonin and norepinephrine reuptake inhibitor that uses dual reuptake inhibition, meaning it increases the levels of both serotonin and norepinephrine. Shortages of norepinephrine and serotonin are thought to play an important role in depression and generalized anxiety disorder. By increasing the levels of norepinephrine and serotonin through a mechanism in the brain called reuptake inhibition, Effexor XR can help to combat depression and generalized anxiety disorder. How do you take it? Effexor XR should be taken in a single daily dose with food, either in the morning or in the evening, at approximately the same time each day. Take each capsule whole, with fluid, and not divide, crush, chew, or place in liquid prior to administration. What are the side effects? While taking Effexor XR, some people may experience nausea, dizziness, sleepiness, delayed ejaculation, sweating, dry mouth, nervousness, insomnia, anorexia, and constipation. Effexor XR may raise blood pressure in some patients, so blood pressure should be monitored regularly. Effexor XR may impair judgment, thinking, or motor skills. What precautions should be taken? Before starting Effexor XR, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. Pregnant or nursing women shouldn't take any antidepressant without consulting their doctor. People taking MAO inhibitors should not take Effexor XR.