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Details SINEMET – (Carbidopa/Levodopa) Packets of 100 x 25/250 Tablets Manufactured by Bristol-Myers Squibb What is it? Sinemet is indicated for the treatment of Parkinson's disease and syndrome. It is useful in relieving many of the symptoms of parkinsonism, particularly rigidity and bradykinesia. Sinemet frequently is helpful in the management of tremor, dysphagia, sialorrhea, and postural instability associated with Parkinson's disease and syndrome. How do you take it? Dosage should be titrated to the individual patient needs and this may require adjusting both the individual dose and the frequency of administration. Take Sinemet as prescribed by your doctor. What are the side effects? More common side effects may include confusion, hallucinations, nausea, uncontrollable twitching or jerking. Less common or rare side effects may include abdominal or stomach pain, abnormal dreams, agitation, anemia, anxiety, back pain, bizarre breathing patterns, bleeding from stomach, blisters, blurred vision, burning sensation of tongue, chest pain, clumsiness in walking, common cold, constipation, convulsions, cough, dark saliva, dark sweat, dark urine, delusions, depression, diarrhea, dilated pupils, disorientation, dizziness, dizziness upon rising from a sitting or lying position, double vision, dream abnormalities, drooling, drowsiness, dry mouth, euphoria, eyelid twitching, faintness, falling, fatigue, fever, flatulence, fluid retention, flushing, hair loss, headache, heart attack, heart palpitations, heartburn, hiccups, high or low blood pressure, hoarseness, hot flashes, increased sex drive, increased tremor, insomnia or other sleep problems, irregular heartbeat, leg pain, locked jaw, loss of appetite, malignant melanoma, memory problems, mental changes, muscle cramps, muscle twitching, nervousness, numbness, "on-off" phenomena, paralysis of certain muscles and unwanted movement of others, paranoia, persistent erection, phlebitis (swelling of a vein), rash, rolling eyes, shortness of breath, shoulder pain, slowed physical movements, sore throat, speech impairment, stomach ulcer, suicidal tendencies, swallowing difficulties, sweating, taste changes, teeth-grinding, tingling or pins and needles, upper respiratory infection, upset stomach, urinary frequency, urinary incontinence, urinary retention, urinary tract infections, weakness, weight loss or gain, writhing or flailing movements, vomiting. What precautions should be taken? Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with Sinemet. These inhibitors must be discontinued at least two weeks prior to initiating therapy with Sinemet. Since levodopa may activate a malignant melanoma, Sinemet should not be used in patients with suspicious undiagnosed skin lesions or a history of melanoma. Advise your doctor of your complete medical history. People who have a history of heart problems should take this medication cautiously, as with people who suffer from wide-angle glaucoma. Use of Sinemet during pregnancy requires that the anticipated benefits to the mother, outweigh the potential risks to the foetus. Tell your doctor immediately should pregnancy occur whilst taking this drug.